Pyrazinamide triggers degradation of its target aspartate decarboxylase

Pyrazinamide is a sterilizing first-line tuberculosis drug. Genetic, metabolomic and biophysical analyses previously demonstrated that pyrazinoic acid, the bioactive form of the prodrug pyrazinamide (PZA), interrupts biosynthesis of coenzyme A in Mycobacterium tuberculosis by binding to aspartate de...

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Detalles Bibliográficos
Autores principales: Gopal, Pooja, Sarathy, Jickky Palmae, Yee, Michelle, Ragunathan, Priya, Shin, Joon, Bhushan, Shashi, Zhu, Junhao, Akopian, Tatos, Kandror, Olga, Lim, Teck Kwang, Gengenbacher, Martin, Lin, Qingsong, Rubin, Eric J., Grüber, Gerhard, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125159/
https://www.ncbi.nlm.nih.gov/pubmed/32245967
http://dx.doi.org/10.1038/s41467-020-15516-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125159/
https://www.ncbi.nlm.nih.gov/pubmed/32245967
http://dx.doi.org/10.1038/s41467-020-15516-1

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