Cargando…

Pyrazinamide triggers degradation of its target aspartate decarboxylase

Pyrazinamide is a sterilizing first-line tuberculosis drug. Genetic, metabolomic and biophysical analyses previously demonstrated that pyrazinoic acid, the bioactive form of the prodrug pyrazinamide (PZA), interrupts biosynthesis of coenzyme A in Mycobacterium tuberculosis by binding to aspartate de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gopal, Pooja, Sarathy, Jickky Palmae, Yee, Michelle, Ragunathan, Priya, Shin, Joon, Bhushan, Shashi, Zhu, Junhao, Akopian, Tatos, Kandror, Olga, Lim, Teck Kwang, Gengenbacher, Martin, Lin, Qingsong, Rubin, Eric J., Grüber, Gerhard, Dick, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125159/ https://www.ncbi.nlm.nih.gov/pubmed/32245967 http://dx.doi.org/10.1038/s41467-020-15516-1

Ejemplares similares

TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug’s Uncoupler Activity
por: Sarathy, Jickky Palmae, et al.
Publicado: (2020)

Re-Understanding the Mechanisms of Action of the Anti-Mycobacterial Drug Bedaquiline
por: Sarathy, Jickky Palmae, et al.
Publicado: (2019)

TBAJ-876 Retains Bedaquiline’s Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase
por: Sarathy, Jickky Palmae, et al.
Publicado: (2019)

Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro
por: Sarathy, Jickky Palmae, et al.
Publicado: (2022)

TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus
por: Sarathy, Jickky Palmae, et al.
Publicado: (2020)

Aspartate decarboxylase (PanD) as a new target of pyrazinamide in Mycobacterium tuberculosis
por: Shi, Wanliang, et al.
Publicado: (2014)

Mutations in panD encoding aspartate decarboxylase are associated with pyrazinamide resistance in Mycobacterium tuberculosis
por: Zhang, Shuo, et al.
Publicado: (2013)

ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria
por: Kester, Jemila C., et al.
Publicado: (2021)

Impact of immunopathology on the antituberculous activity of pyrazinamide
por: Blanc, Landry, et al.
Publicado: (2018)

In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1
por: Gopal, Pooja, et al.
Publicado: (2017)

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis
por: Saw, Wuan-Geok, et al.
Publicado: (2019)

Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection
por: Raju, Ravikiran M., et al.
Publicado: (2012)

Alkyltriphenylphosphonium turns naphthoquinoneimidazoles into potent membrane depolarizers against mycobacteria
por: Fridianto, Kevin Timothy, et al.
Publicado: (2022)

Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis
por: Yee, Michelle, et al.
Publicado: (2017)

Pyrazinamide induced thrombocytopenia
por: Kant, Surya, et al.
Publicado: (2010)

Chemoinformatic Identification of Novel Inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase
por: Sharma, Reetu, et al.
Publicado: (2012)

Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase
por: Webb, Michael E., et al.
Publicado: (2014)

Aspartate Decarboxylase is Required for a Normal Pupa Pigmentation Pattern in the Silkworm, Bombyx mori
por: Dai, Fangyin, et al.
Publicado: (2015)

Structure and diffusive dynamics of aspartate α-decarboxylase (ADC) liganded with d-serine in aqueous solution
por: Raskar, Tushar, et al.
Publicado: (2022)

Aspartate α-decarboxylase a new therapeutic target in the fight against Helicobacter pylori infection
por: Ibrahim, Kareem A., et al.
Publicado: (2022)

PYRAZINAMIDE-INDUCED MACULOPAPULAR RASH
por: Khayyam, Khalid Umer, et al.
Publicado: (2010)

Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action
por: Weinhäupl, Katharina, et al.
Publicado: (2022)

PanM, an Acetyl-Coenzyme A Sensor Required for Maturation of l-Aspartate Decarboxylase (PanD)
por: Stuecker, Tara N., et al.
Publicado: (2012)

AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C
por: Wong, Chui Fann, et al.
Publicado: (2017)

Pyrazinamide may possess cardioprotective properties
por: Sinha, Sharabh, et al.
Publicado: (2019)

Detection of Pyrazinamide Heteroresistance in Mycobacterium tuberculosis
por: Werngren, Jim, et al.
Publicado: (2021)

Pyrazinamide resistance in rifampicin discordant tuberculosis
por: Mvelase, Nomonde Ritta, et al.
Publicado: (2022)

Dynamics and disorder: on the stability of pyrazinamide polymorphs
por: Hoser, Anna Agnieszka, et al.
Publicado: (2022)

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide
por: Yadon, Adam N., et al.
Publicado: (2017)

Thermostable D-amino acid decarboxylases derived from Thermotoga maritima diaminopimelate decarboxylase
por: Marjanovic, Antonija, et al.
Publicado: (2021)

A case of thrombocytopenia caused by rifampicin and pyrazinamide
por: Bansal, Rekha, et al.
Publicado: (2013)

Revisiting Anti-tuberculosis Activity of Pyrazinamide in Mice
por: Almeida, Deepak V., et al.
Publicado: (2014)

Serum pyrazinamide concentrations in patients with pulmonary tuberculosis
por: Lucena, Stefania de Medeiros Araujo, et al.
Publicado: (2019)

Calcitriol enhances pyrazinamide treatment of murine tuberculosis
por: Zhang, Jing, et al.
Publicado: (2019)

Impact of the host environment on the antitubercular action of pyrazinamide
por: Lamont, Elise A., et al.
Publicado: (2019)

Molecular analysis of pyrazinamide resistance in Mycobacterium tuberculosis in Vietnam highlights the high rate of pyrazinamide resistance-associated mutations in clinical isolates
por: Huy, Nguyen Quang, et al.
Publicado: (2017)

Underestimated pyrazinamide resistance may compromise outcomes of pyrazinamide containing regimens for treatment of drug susceptible and multi-drug-resistant tuberculosis in Tanzania
por: Juma, Saumu Pazia, et al.
Publicado: (2019)

Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia
por: Sengstake, Sarah, et al.
Publicado: (2017)

An activator for pyruvoyl-dependent l-aspartate α-decarboxylase is conserved in a small group of the γ-proteobacteria including Escherichia coli
por: Nozaki, Shingo, et al.
Publicado: (2012)

Enhancement of cyclophosphamide cytotoxicity in vivo by the benzamide analogue pyrazinamide.
por: Horsman, M. R., et al.
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_mt3n0qr7c7220a24pm64s40ng7