Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity

Gentamicin is a nephrotoxic antibiotic that causes acute kidney injury (AKI) primarily by targeting the proximal tubule epithelial cell. The development of an effective therapy for gentamicin-induced renal cell injury is limited by incomplete mechanistic insight. To address this challenge, we propos...

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Detalles Bibliográficos
Autores principales: Igwebuike, Chinaemere, Yaglom, Julia, Huiting, Leah, Feng, Hui, Campbell, Joshua D., Wang, Zhiyong, Havasi, Andrea, Pimentel, David, Sherman, Michael Y., Borkan, Steven C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125232/
https://www.ncbi.nlm.nih.gov/pubmed/32245975
http://dx.doi.org/10.1038/s41419-020-2382-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125232/
https://www.ncbi.nlm.nih.gov/pubmed/32245975
http://dx.doi.org/10.1038/s41419-020-2382-7

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