Prediction of exposure-driven myelotoxicity of continuous infusion 5-fluorouracil by a semi-physiological pharmacokinetic–pharmacodynamic model in gastrointestinal cancer patients

PURPOSE: To describe 5-fluorouracil (5FU) pharmacokinetics, myelotoxicity and respective covariates using a simultaneous nonlinear mixed effect modelling approach. METHODS: Thirty patients with gastrointestinal cancer received 5FU 650 or 1000 mg/m(2)/day as 5-day continuous venous infusion (14 of wh...

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Detalles Bibliográficos
Autores principales: Arshad, Usman, Ploylearmsaeng, Su-arpa, Karlsson, Mats O., Doroshyenko, Oxana, Langer, Dorothee, Schömig, Edgar, Kunze, Sabine, Güner, Semih A., Skripnichenko, Roman, Ullah, Sami, Jaehde, Ulrich, Fuhr, Uwe, Jetter, Alexander, Taubert, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125253/
https://www.ncbi.nlm.nih.gov/pubmed/32152679
http://dx.doi.org/10.1007/s00280-019-04028-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125253/
https://www.ncbi.nlm.nih.gov/pubmed/32152679
http://dx.doi.org/10.1007/s00280-019-04028-5

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