The quaternary assembly of KRas4B with Raf-1 at the membrane

Proximally located in the membrane, oncogenic Ras dimers (or nanoclusters) can recruit and promote Raf dimerization and MAPK (Raf/MEK/ERK) signaling. Among Ras isoforms, KRas4B is the most frequently mutated. Recent data on the binary KRas4B–Raf-1 complex suggested that Raf-1 CRD not only executes m...

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Detalles Bibliográficos
Autores principales: Jang, Hyunbum, Zhang, Mingzhen, Nussinov, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125320/
https://www.ncbi.nlm.nih.gov/pubmed/32257057
http://dx.doi.org/10.1016/j.csbj.2020.03.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125320/
https://www.ncbi.nlm.nih.gov/pubmed/32257057
http://dx.doi.org/10.1016/j.csbj.2020.03.018

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