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Cyclophilin inhibitors as antiviral agents

Cyclophilins (Cyps) are ubiquitous proteins that effect the cis–trans isomerization of Pro amide bonds, and are thus crucial to protein folding. CypA is the most prevalent of the ∼19 human Cyps, and plays a crucial role in viral infectivity, most notably for HIV-1 and HCV. Cyclophilins have been sho...

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Detalles Bibliográficos
Autores principales: Peel, Michael, Scribner, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125669/
https://www.ncbi.nlm.nih.gov/pubmed/23849880
http://dx.doi.org/10.1016/j.bmcl.2013.05.101