Molecular characterization of hepatitis E virus ORF1 gene supports a papain-like cysteine protease (PCP)-domain activity

Hepatitis E Virus (HEV) ORF1 encodes the nonstructural polyprotein wherein a role of PCP-domain in ORF1 proteolysis and/or RNA replication still remains contested. A series of ORF1 mutants of HEV-SAR(55) replicon were constructed and tested for viability in S10-3 cells. Six of PCP-‘cysteine’ (C457A,...

Descripción completa

Detalles Bibliográficos
Autor principal: Parvez, Mohammad Khalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125709/
https://www.ncbi.nlm.nih.gov/pubmed/23978667
http://dx.doi.org/10.1016/j.virusres.2013.07.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125709/
https://www.ncbi.nlm.nih.gov/pubmed/23978667
http://dx.doi.org/10.1016/j.virusres.2013.07.020

Ejemplares similares