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Molecular characterization of hepatitis E virus ORF1 gene supports a papain-like cysteine protease (PCP)-domain activity

Hepatitis E Virus (HEV) ORF1 encodes the nonstructural polyprotein wherein a role of PCP-domain in ORF1 proteolysis and/or RNA replication still remains contested. A series of ORF1 mutants of HEV-SAR(55) replicon were constructed and tested for viability in S10-3 cells. Six of PCP-‘cysteine’ (C457A,...

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Detalles Bibliográficos
Autor principal:	Parvez, Mohammad Khalid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2013
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125709/ https://www.ncbi.nlm.nih.gov/pubmed/23978667 http://dx.doi.org/10.1016/j.virusres.2013.07.020

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