Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action

The related 3C and 3C-like proteinase (3C(pro) and 3CL(pro)) of picornaviruses and coronaviruses, respectively, are good drug targets. As part of an effort to generate broad-spectrum inhibitors of these enzymes, we screened a library of inhibitors based on a halopyridinyl ester from a previous study...

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Detalles Bibliográficos
Autores principales: Huitema, Carly, Zhang, Jianmin, Yin, Jiang, James, Michael N.G., Vederas, John C., Eltis, Lindsay D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125897/
https://www.ncbi.nlm.nih.gov/pubmed/18407505
http://dx.doi.org/10.1016/j.bmc.2008.03.059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125897/
https://www.ncbi.nlm.nih.gov/pubmed/18407505
http://dx.doi.org/10.1016/j.bmc.2008.03.059

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