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Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action
The related 3C and 3C-like proteinase (3C(pro) and 3CL(pro)) of picornaviruses and coronaviruses, respectively, are good drug targets. As part of an effort to generate broad-spectrum inhibitors of these enzymes, we screened a library of inhibitors based on a halopyridinyl ester from a previous study...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125897/ https://www.ncbi.nlm.nih.gov/pubmed/18407505 http://dx.doi.org/10.1016/j.bmc.2008.03.059 |