Evaluation of antirotavirus activity of flavonoids

Flavonoids are dietary components and the most ubiquitous phenolic compounds found in nature, showing a range of pharmacological activities including antiviral action. This study describes the antiviral screening of 60 different flavones and flavonols against human rotavirus (Wa-1 strain) as well as...

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Detalles Bibliográficos
Autores principales: Savi, Luciane Anita, Caon, Thiago, de Oliveira, Ana Paula, Sobottka, Andrea Michel, Werner, Wolfgang, Reginatto, Flávio Henrique, Schenkel, Eloir Paulo, Barardi, Célia Regina Monte, Simões, Cláudia Maria Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126014/
https://www.ncbi.nlm.nih.gov/pubmed/20659535
http://dx.doi.org/10.1016/j.fitote.2010.07.017
Descripción
Sumario:Flavonoids are dietary components and the most ubiquitous phenolic compounds found in nature, showing a range of pharmacological activities including antiviral action. This study describes the antiviral screening of 60 different flavones and flavonols against human rotavirus (Wa-1 strain) as well as their cytotoxicity in MA104 cells. Cytotoxicity was investigated by cell morphology assessment and antirotavirus activity by cytopathic effect inhibition. Results were expressed as CC(50) and IC(50), respectively, in order to calculate the selectivity index (SI = CC(50)/IC(50)) of each compound. Structure–activity relationships (SAR) were proposed based on antirotavirus activity.

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