Evaluation of antirotavirus activity of flavonoids

Flavonoids are dietary components and the most ubiquitous phenolic compounds found in nature, showing a range of pharmacological activities including antiviral action. This study describes the antiviral screening of 60 different flavones and flavonols against human rotavirus (Wa-1 strain) as well as...

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Autores principales: Savi, Luciane Anita, Caon, Thiago, de Oliveira, Ana Paula, Sobottka, Andrea Michel, Werner, Wolfgang, Reginatto, Flávio Henrique, Schenkel, Eloir Paulo, Barardi, Célia Regina Monte, Simões, Cláudia Maria Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126014/
https://www.ncbi.nlm.nih.gov/pubmed/20659535
http://dx.doi.org/10.1016/j.fitote.2010.07.017
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author Savi, Luciane Anita
Caon, Thiago
de Oliveira, Ana Paula
Sobottka, Andrea Michel
Werner, Wolfgang
Reginatto, Flávio Henrique
Schenkel, Eloir Paulo
Barardi, Célia Regina Monte
Simões, Cláudia Maria Oliveira
author_facet Savi, Luciane Anita
Caon, Thiago
de Oliveira, Ana Paula
Sobottka, Andrea Michel
Werner, Wolfgang
Reginatto, Flávio Henrique
Schenkel, Eloir Paulo
Barardi, Célia Regina Monte
Simões, Cláudia Maria Oliveira
author_sort Savi, Luciane Anita
collection PubMed
description Flavonoids are dietary components and the most ubiquitous phenolic compounds found in nature, showing a range of pharmacological activities including antiviral action. This study describes the antiviral screening of 60 different flavones and flavonols against human rotavirus (Wa-1 strain) as well as their cytotoxicity in MA104 cells. Cytotoxicity was investigated by cell morphology assessment and antirotavirus activity by cytopathic effect inhibition. Results were expressed as CC(50) and IC(50), respectively, in order to calculate the selectivity index (SI = CC(50)/IC(50)) of each compound. Structure–activity relationships (SAR) were proposed based on antirotavirus activity.
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spelling pubmed-71260142020-04-08 Evaluation of antirotavirus activity of flavonoids Savi, Luciane Anita Caon, Thiago de Oliveira, Ana Paula Sobottka, Andrea Michel Werner, Wolfgang Reginatto, Flávio Henrique Schenkel, Eloir Paulo Barardi, Célia Regina Monte Simões, Cláudia Maria Oliveira Fitoterapia Article Flavonoids are dietary components and the most ubiquitous phenolic compounds found in nature, showing a range of pharmacological activities including antiviral action. This study describes the antiviral screening of 60 different flavones and flavonols against human rotavirus (Wa-1 strain) as well as their cytotoxicity in MA104 cells. Cytotoxicity was investigated by cell morphology assessment and antirotavirus activity by cytopathic effect inhibition. Results were expressed as CC(50) and IC(50), respectively, in order to calculate the selectivity index (SI = CC(50)/IC(50)) of each compound. Structure–activity relationships (SAR) were proposed based on antirotavirus activity. Elsevier B.V. 2010-12 2010-07-24 /pmc/articles/PMC7126014/ /pubmed/20659535 http://dx.doi.org/10.1016/j.fitote.2010.07.017 Text en Copyright © 2010 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Savi, Luciane Anita
Caon, Thiago
de Oliveira, Ana Paula
Sobottka, Andrea Michel
Werner, Wolfgang
Reginatto, Flávio Henrique
Schenkel, Eloir Paulo
Barardi, Célia Regina Monte
Simões, Cláudia Maria Oliveira
Evaluation of antirotavirus activity of flavonoids
title Evaluation of antirotavirus activity of flavonoids
title_full Evaluation of antirotavirus activity of flavonoids
title_fullStr Evaluation of antirotavirus activity of flavonoids
title_full_unstemmed Evaluation of antirotavirus activity of flavonoids
title_short Evaluation of antirotavirus activity of flavonoids
title_sort evaluation of antirotavirus activity of flavonoids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126014/
https://www.ncbi.nlm.nih.gov/pubmed/20659535
http://dx.doi.org/10.1016/j.fitote.2010.07.017
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