Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors

3-Acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives were synthesized and evaluated to show high anti-MERS-CoV inhibitory activities. Among them, 6,8-difluoro-3-isobutyryl-2-((2,3,4-trifluorophenyl)amino)quinolin-4(1H)-one (6u) exhibits high inhibitory effect (IC(50) = 86 nM) and low toxic...

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Detalles Bibliográficos
Autores principales: Yoon, Ji Hye, Lee, Jun Young, Lee, Jihye, Shin, Young Sup, Jeon, Sangeun, Kim, Dong Eon, Min, Jung Sun, Song, Jong Hwan, Kim, Seungtaek, Kwon, Sunoh, Jin, Young-hee, Jang, Min Seong, Kim, Hyoung Rae, Park, Chul Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126094/
https://www.ncbi.nlm.nih.gov/pubmed/31624041
http://dx.doi.org/10.1016/j.bmcl.2019.126727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126094/
https://www.ncbi.nlm.nih.gov/pubmed/31624041
http://dx.doi.org/10.1016/j.bmcl.2019.126727

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