Old drugs as lead compounds for a new disease? Binding analysis of SARS coronavirus main proteinase with HIV, psychotic and parasite drugs

The SARS-associated coronavirus (SARS-CoV) main proteinase is a key enzyme in viral polyprotein processing. To allow structure-based design of drugs directed at SARS-CoV main proteinase, we predicted its binding pockets and affinities with existing HIV, psychotic and parasite drugs (lopinavir, riton...

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Detalles Bibliográficos
Autores principales: Zhang, Xue Wu, Yap, Yee Leng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126105/
https://www.ncbi.nlm.nih.gov/pubmed/15110833
http://dx.doi.org/10.1016/j.bmc.2004.03.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126105/
https://www.ncbi.nlm.nih.gov/pubmed/15110833
http://dx.doi.org/10.1016/j.bmc.2004.03.035

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