Synthesis and antiviral activity evaluation of acyclic 2′-azanucleosides bearing a phosphonomethoxy function in the side chain

Acyclic 2′-azanucleosides with a phosphonomethoxy function in the side chain were obtained by coupling of diethyl {2-[N-(pivaloyloxymethyl)-N-(p-toluenesulfonyl)amino]ethoxymethyl}phosphonate with the pyrimidine nucleobases via the Vorbrüggen-type protocol. The compounds were evaluated in vitro for...

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Detalles Bibliográficos
Autores principales: Koszytkowska-Stawińska, Mariola, Clercq, Erik De, Balzarini, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126109/
https://www.ncbi.nlm.nih.gov/pubmed/19442526
http://dx.doi.org/10.1016/j.bmc.2009.04.054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126109/
https://www.ncbi.nlm.nih.gov/pubmed/19442526
http://dx.doi.org/10.1016/j.bmc.2009.04.054

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