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Synthesis and antiviral activity evaluation of acyclic 2′-azanucleosides bearing a phosphonomethoxy function in the side chain

Acyclic 2′-azanucleosides with a phosphonomethoxy function in the side chain were obtained by coupling of diethyl {2-[N-(pivaloyloxymethyl)-N-(p-toluenesulfonyl)amino]ethoxymethyl}phosphonate with the pyrimidine nucleobases via the Vorbrüggen-type protocol. The compounds were evaluated in vitro for...

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Detalles Bibliográficos
Autores principales:	Koszytkowska-Stawińska, Mariola, Clercq, Erik De, Balzarini, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126109/ https://www.ncbi.nlm.nih.gov/pubmed/19442526 http://dx.doi.org/10.1016/j.bmc.2009.04.054

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