First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via ‘privileged scaffold’ refining approach

A series of 1,2,3-triazolyl 3-hydroxy-quinazoline-2,4(1H,3H)-diones was constructed utilizing Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) method. The biological significance of the novel synthesized quinazolines was highlighted by evaluating them in vitro for antiviral activity, w...

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Detalles Bibliográficos
Autores principales: Kang, Dongwei, Zhang, Heng, Zhou, Zhongxia, Huang, Boshi, Naesens, Lieve, Zhan, Peng, Liu, Xinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126219/
https://www.ncbi.nlm.nih.gov/pubmed/27742238
http://dx.doi.org/10.1016/j.bmcl.2016.09.071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126219/
https://www.ncbi.nlm.nih.gov/pubmed/27742238
http://dx.doi.org/10.1016/j.bmcl.2016.09.071

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