Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity

Actinomycin D and nutlin-3a (A + N) activate p53, partly through induction of phosphorylation on Ser392. The death of A549 cells induced by A + N morphologically resembles inflammation-inducing pyroptosis - cell destruction triggered by activated caspase-1. The treatment with A + N (or camptothecin)...

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Detalles Bibliográficos
Autores principales: Krześniak, Małgorzata, Zajkowicz, Artur, Gdowicz-Kłosok, Agnieszka, Głowala-Kosińska, Magdalena, Łasut-Szyszka, Barbara, Rusin, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126238/
https://www.ncbi.nlm.nih.gov/pubmed/32032660
http://dx.doi.org/10.1016/j.cellsig.2020.109552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126238/
https://www.ncbi.nlm.nih.gov/pubmed/32032660
http://dx.doi.org/10.1016/j.cellsig.2020.109552

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