2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents

A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC(50) value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59,...

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Autores principales: Hsieh, Pei-Wen, Chang, Fang-Rong, Chang, Cheng-Hsien, Cheng, Pei-Wen, Chiang, Lien-Chai, Zeng, Fu-Long, Lin, Kuei-Hsiang, Wu, Yang-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126427/
https://www.ncbi.nlm.nih.gov/pubmed/15324901
http://dx.doi.org/10.1016/j.bmcl.2004.06.083
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author Hsieh, Pei-Wen
Chang, Fang-Rong
Chang, Cheng-Hsien
Cheng, Pei-Wen
Chiang, Lien-Chai
Zeng, Fu-Long
Lin, Kuei-Hsiang
Wu, Yang-Chang
author_facet Hsieh, Pei-Wen
Chang, Fang-Rong
Chang, Cheng-Hsien
Cheng, Pei-Wen
Chiang, Lien-Chai
Zeng, Fu-Long
Lin, Kuei-Hsiang
Wu, Yang-Chang
author_sort Hsieh, Pei-Wen
collection PubMed
description A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC(50) value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED(50) values of 1 and 6 are 1.00 and 0.50 μg/mL, respectively.
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spelling pubmed-71264272020-04-08 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents Hsieh, Pei-Wen Chang, Fang-Rong Chang, Cheng-Hsien Cheng, Pei-Wen Chiang, Lien-Chai Zeng, Fu-Long Lin, Kuei-Hsiang Wu, Yang-Chang Bioorg Med Chem Lett Article A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC(50) value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED(50) values of 1 and 6 are 1.00 and 0.50 μg/mL, respectively. Elsevier Ltd. 2004-09-20 2004-07-31 /pmc/articles/PMC7126427/ /pubmed/15324901 http://dx.doi.org/10.1016/j.bmcl.2004.06.083 Text en Copyright © 2004 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hsieh, Pei-Wen
Chang, Fang-Rong
Chang, Cheng-Hsien
Cheng, Pei-Wen
Chiang, Lien-Chai
Zeng, Fu-Long
Lin, Kuei-Hsiang
Wu, Yang-Chang
2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents
title 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents
title_full 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents
title_fullStr 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents
title_full_unstemmed 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents
title_short 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents
title_sort 2-substituted benzoxazinone analogues as anti-human coronavirus (anti-hcov) and icam-1 expression inhibition agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126427/
https://www.ncbi.nlm.nih.gov/pubmed/15324901
http://dx.doi.org/10.1016/j.bmcl.2004.06.083
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