Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement

An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplas...

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Autores principales: Kleinau, Sandra, Erlandsson, Helena, Holmdahl, Rikard, Klareskog, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1991
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126449/
https://www.ncbi.nlm.nih.gov/pubmed/1812893
http://dx.doi.org/10.1016/0896-8411(91)90050-M
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author Kleinau, Sandra
Erlandsson, Helena
Holmdahl, Rikard
Klareskog, Lars
author_facet Kleinau, Sandra
Erlandsson, Helena
Holmdahl, Rikard
Klareskog, Lars
author_sort Kleinau, Sandra
collection PubMed
description An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel(®) A, as well as Pristane oil were arthritogenic, whereas vegetable oils were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.
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spelling pubmed-71264492020-04-08 Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement Kleinau, Sandra Erlandsson, Helena Holmdahl, Rikard Klareskog, Lars J Autoimmun Article An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel(®) A, as well as Pristane oil were arthritogenic, whereas vegetable oils were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats. Published by Elsevier Ltd. 1991-12 2004-02-04 /pmc/articles/PMC7126449/ /pubmed/1812893 http://dx.doi.org/10.1016/0896-8411(91)90050-M Text en Copyright © 1991 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Kleinau, Sandra
Erlandsson, Helena
Holmdahl, Rikard
Klareskog, Lars
Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement
title Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement
title_full Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement
title_fullStr Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement
title_full_unstemmed Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement
title_short Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement
title_sort adjuvant oils induce arthritis in the da rat. i. characterization of the disease and evidence for an immunological involvement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126449/
https://www.ncbi.nlm.nih.gov/pubmed/1812893
http://dx.doi.org/10.1016/0896-8411(91)90050-M
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