The Matrix Protein VP40 from Ebola Virus Octamerizes into Pore-like Structures with Specific RNA Binding Properties

The Ebola virus membrane-associated matrix protein VP40 is thought to be crucial for assembly and budding of virus particles. Here we present the crystal structure of a disk-shaped octameric form of VP40 formed by four antiparallel homodimers of the N-terminal domain. The octamer binds an RNA tririb...

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Detalles Bibliográficos
Autores principales: Gomis-Rüth, F.Xavier, Dessen, Andréa, Timmins, Joanna, Bracher, Andreas, Kolesnikowa, Larissa, Becker, Stephan, Klenk, Hans-Dieter, Weissenhorn, Winfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press. Published by Elsevier Ltd. 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126486/
https://www.ncbi.nlm.nih.gov/pubmed/12679020
http://dx.doi.org/10.1016/S0969-2126(03)00050-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126486/
https://www.ncbi.nlm.nih.gov/pubmed/12679020
http://dx.doi.org/10.1016/S0969-2126(03)00050-9

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