Exploring the purine core of 3′-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics

A series of new nucleoside analogues based on a C-3 branched ethynyl sugar derivative as present in 3′-C-ethynylcytidine (ECyd) and -adenosine (EAdo), combined with modified purine bases was synthetized and evaluated against a broad array of viruses and tumour cell lines. The pronounced cytostatic a...

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Detalles Bibliográficos
Autores principales: Hulpia, Fabian, Balzarini, Jan, Schols, Dominique, Andrei, Graciela, Snoeck, Robert, Van Calenbergh, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126545/
https://www.ncbi.nlm.nih.gov/pubmed/26965865
http://dx.doi.org/10.1016/j.bmcl.2016.03.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126545/
https://www.ncbi.nlm.nih.gov/pubmed/26965865
http://dx.doi.org/10.1016/j.bmcl.2016.03.005

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