Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs

The importance of phosphonoamidate prodrugs (ProTides) of acyclic nucleoside phosphonate (ANPs) is highlighted by the approval of Tenofovir Alafenamide Fumarate for the treatment of HIV and HBV infections. In the present paper we are reporting an expedient, one-pot, two-steps synthesis of allyl phos...

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Detalles Bibliográficos
Autores principales: Pileggi, Elisa, Serpi, Michaela, Andrei, Graciela, Schols, Dominique, Snoeck, Robert, Pertusati, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126595/
https://www.ncbi.nlm.nih.gov/pubmed/29880251
http://dx.doi.org/10.1016/j.bmc.2018.05.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126595/
https://www.ncbi.nlm.nih.gov/pubmed/29880251
http://dx.doi.org/10.1016/j.bmc.2018.05.034

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