Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant

The 3C-like (3CL) protease of the severe acute respiratory syndrome (SARS) coronavirus is a key enzyme for the virus maturation. We found for the first time that the mature SARS 3CL protease is subject to degradation at 188Arg/189Gln. Replacing Arg with Ile at position 188 rendered the protease resi...

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Detalles Bibliográficos
Autores principales: Akaji, Kenichi, Konno, Hiroyuki, Onozuka, Mari, Makino, Ayumi, Saito, Hiroyuki, Nosaka, Kazuto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126698/
https://www.ncbi.nlm.nih.gov/pubmed/18845442
http://dx.doi.org/10.1016/j.bmc.2008.09.057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126698/
https://www.ncbi.nlm.nih.gov/pubmed/18845442
http://dx.doi.org/10.1016/j.bmc.2008.09.057

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