Virtual screening identification of novel severe acute respiratory syndrome 3C-like protease inhibitors and in vitro confirmation

The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome associated coronavirus (SARS-CoV) is vital for SARS-CoV replication and is a promising drug target. Structure based virtual screening of 308 307 chemical compounds was performed using the computation tool Autodock 3.0.5 on a WISDOM...

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Detalles Bibliográficos
Autores principales: Hanh Nguyen, Thi Thanh, Ryu, Hwa-Ja, Lee, Se-Hoon, Hwang, Soonwook, Breton, Vincent, Rhee, Joon Haeng, Kim, Doman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126700/
https://www.ncbi.nlm.nih.gov/pubmed/21470860
http://dx.doi.org/10.1016/j.bmcl.2011.03.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126700/
https://www.ncbi.nlm.nih.gov/pubmed/21470860
http://dx.doi.org/10.1016/j.bmcl.2011.03.034

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