Why G3139 works poorly in cancer trials but might work well against HIV

The antisense drug G3139 (oblimersen sodium, Genta, Inc.) is a phosphorothioate oligodeoxynucleotide (ODN) containing unmethylated CpG units, which is targeted to suppress Bcl-2. To date, its effectiveness in cancer clinical trials has been minimal. Some suggestions are provided for that disappointm...

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Detalles Bibliográficos
Autor principal: Parris, George E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126701/
https://www.ncbi.nlm.nih.gov/pubmed/17363184
http://dx.doi.org/10.1016/j.mehy.2007.01.044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126701/
https://www.ncbi.nlm.nih.gov/pubmed/17363184
http://dx.doi.org/10.1016/j.mehy.2007.01.044

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