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Why G3139 works poorly in cancer trials but might work well against HIV
The antisense drug G3139 (oblimersen sodium, Genta, Inc.) is a phosphorothioate oligodeoxynucleotide (ODN) containing unmethylated CpG units, which is targeted to suppress Bcl-2. To date, its effectiveness in cancer clinical trials has been minimal. Some suggestions are provided for that disappointm...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Ltd.
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126701/ https://www.ncbi.nlm.nih.gov/pubmed/17363184 http://dx.doi.org/10.1016/j.mehy.2007.01.044 |