5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties

Synthetically combining the C-4′ side-chain structural features of the antiviral candidates 5′-methylaristeromycin and 5′-homoaristeromycin into a diastereomeric pair of C-4′ side-chain dihydroxylated aristeromycins (6 and 7) is reported. Broad antiviral analyses of the both targets found promising...

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Detalles Bibliográficos
Autores principales: Chen, Qi, Liu, Chong, Bowlin, Terry L., Schneller, Stewart W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126772/
https://www.ncbi.nlm.nih.gov/pubmed/29628328
http://dx.doi.org/10.1016/j.bmcl.2018.03.088
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author Chen, Qi
Liu, Chong
Bowlin, Terry L.
Schneller, Stewart W.
author_facet Chen, Qi
Liu, Chong
Bowlin, Terry L.
Schneller, Stewart W.
author_sort Chen, Qi
collection PubMed
description Synthetically combining the C-4′ side-chain structural features of the antiviral candidates 5′-methylaristeromycin and 5′-homoaristeromycin into a diastereomeric pair of C-4′ side-chain dihydroxylated aristeromycins (6 and 7) is reported. Broad antiviral analyses of the both targets found promising effects towards HBV (6, 6.7 μM and 7, 7.74 μM) and HCMV (only 7, 0.72 μM). No other activity was found. Neither of the diastereomers was cytotoxic in the assays performed.
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spelling pubmed-71267722020-04-08 5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties Chen, Qi Liu, Chong Bowlin, Terry L. Schneller, Stewart W. Bioorg Med Chem Lett Article Synthetically combining the C-4′ side-chain structural features of the antiviral candidates 5′-methylaristeromycin and 5′-homoaristeromycin into a diastereomeric pair of C-4′ side-chain dihydroxylated aristeromycins (6 and 7) is reported. Broad antiviral analyses of the both targets found promising effects towards HBV (6, 6.7 μM and 7, 7.74 μM) and HCMV (only 7, 0.72 μM). No other activity was found. Neither of the diastereomers was cytotoxic in the assays performed. Elsevier Ltd. 2018-05-15 2018-03-31 /pmc/articles/PMC7126772/ /pubmed/29628328 http://dx.doi.org/10.1016/j.bmcl.2018.03.088 Text en © 2018 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Chen, Qi
Liu, Chong
Bowlin, Terry L.
Schneller, Stewart W.
5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties
title 5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties
title_full 5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties
title_fullStr 5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties
title_full_unstemmed 5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties
title_short 5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties
title_sort 5′-hydroxy-5′-homoaristeromycin: synthesis and antiviral properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126772/
https://www.ncbi.nlm.nih.gov/pubmed/29628328
http://dx.doi.org/10.1016/j.bmcl.2018.03.088
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