Synthesis, cytotoxic activity, and SAR analysis of the derivatives of taxchinin A and brevifoliol

Twenty-one derivatives of taxchinin A (1) and brevifoliol (2) were synthesized and evaluated for cytotoxicity against human non-small lung cancer (A549) cell line. Nine derivatives showed potent activity with IC(50) values from 0.48 to 6.22 μM. 5-Oxo-13-TBDMS-taxchinin A (11) and 5-oxo-13,15-epoxy-1...

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Detalles Bibliográficos
Autores principales: Zhao, Yu, Guo, Na, Lou, Li-Guang, Cong, Yu-Wen, Peng, Li-Yan, Zhao, Qin-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126827/
https://www.ncbi.nlm.nih.gov/pubmed/18381240
http://dx.doi.org/10.1016/j.bmc.2008.03.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126827/
https://www.ncbi.nlm.nih.gov/pubmed/18381240
http://dx.doi.org/10.1016/j.bmc.2008.03.041

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