Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease

A series of 2-(benzylthio)-6-oxo-4-phenyl-1,6-dihydropyrimidine as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Two candidates had encouraging results for the development of new anti-SARS compounds.

Detalles Bibliográficos
Autores principales: Ramajayam, R., Tan, Kian-Pin, Liu, Hun-Ge, Liang, Po-Huang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126861/
https://www.ncbi.nlm.nih.gov/pubmed/20494577
http://dx.doi.org/10.1016/j.bmcl.2010.04.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126861/
https://www.ncbi.nlm.nih.gov/pubmed/20494577
http://dx.doi.org/10.1016/j.bmcl.2010.04.118

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