Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease

A series of 2-(benzylthio)-6-oxo-4-phenyl-1,6-dihydropyrimidine as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Two candidates had encouraging results for the development of new anti-SARS compounds.

Detalles Bibliográficos
Autores principales: Ramajayam, R., Tan, Kian-Pin, Liu, Hun-Ge, Liang, Po-Huang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126861/
https://www.ncbi.nlm.nih.gov/pubmed/20494577
http://dx.doi.org/10.1016/j.bmcl.2010.04.118
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author Ramajayam, R.
Tan, Kian-Pin
Liu, Hun-Ge
Liang, Po-Huang
author_facet Ramajayam, R.
Tan, Kian-Pin
Liu, Hun-Ge
Liang, Po-Huang
author_sort Ramajayam, R.
collection PubMed
description A series of 2-(benzylthio)-6-oxo-4-phenyl-1,6-dihydropyrimidine as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Two candidates had encouraging results for the development of new anti-SARS compounds.
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spelling pubmed-71268612020-04-08 Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease Ramajayam, R. Tan, Kian-Pin Liu, Hun-Ge Liang, Po-Huang Bioorg Med Chem Lett Article A series of 2-(benzylthio)-6-oxo-4-phenyl-1,6-dihydropyrimidine as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Two candidates had encouraging results for the development of new anti-SARS compounds. Elsevier Ltd. 2010-06-15 2010-04-30 /pmc/articles/PMC7126861/ /pubmed/20494577 http://dx.doi.org/10.1016/j.bmcl.2010.04.118 Text en Copyright © 2010 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ramajayam, R.
Tan, Kian-Pin
Liu, Hun-Ge
Liang, Po-Huang
Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
title Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
title_full Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
title_fullStr Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
title_full_unstemmed Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
title_short Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
title_sort synthesis, docking studies, and evaluation of pyrimidines as inhibitors of sars-cov 3cl protease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126861/
https://www.ncbi.nlm.nih.gov/pubmed/20494577
http://dx.doi.org/10.1016/j.bmcl.2010.04.118
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