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Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
A series of 2-(benzylthio)-6-oxo-4-phenyl-1,6-dihydropyrimidine as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Two candidates had encouraging results for the development of new anti-SARS compounds.
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126861/ https://www.ncbi.nlm.nih.gov/pubmed/20494577 http://dx.doi.org/10.1016/j.bmcl.2010.04.118 |