Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents

Nucleoside analogues that have 6-chloropurine as the nucleobase were synthesized and evaluated for anti-SARS-CoV activity by plaque reduction and yield reduction assays in order to develop novel anti-SARS-CoV agents. Among these analogues, two compounds, namely, 1 and 11, exhibited promising anti-SA...

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Detalles Bibliográficos
Autores principales: Ikejiri, Masahiro, Saijo, Masayuki, Morikawa, Shigeru, Fukushi, Shuetsu, Mizutani, Tetsuya, Kurane, Ichiro, Maruyama, Tokumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126875/
https://www.ncbi.nlm.nih.gov/pubmed/17336519
http://dx.doi.org/10.1016/j.bmcl.2007.02.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126875/
https://www.ncbi.nlm.nih.gov/pubmed/17336519
http://dx.doi.org/10.1016/j.bmcl.2007.02.026

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