Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents

Nucleoside analogues that have 6-chloropurine as the nucleobase were synthesized and evaluated for anti-SARS-CoV activity by plaque reduction and yield reduction assays in order to develop novel anti-SARS-CoV agents. Among these analogues, two compounds, namely, 1 and 11, exhibited promising anti-SA...

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Autores principales: Ikejiri, Masahiro, Saijo, Masayuki, Morikawa, Shigeru, Fukushi, Shuetsu, Mizutani, Tetsuya, Kurane, Ichiro, Maruyama, Tokumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126875/
https://www.ncbi.nlm.nih.gov/pubmed/17336519
http://dx.doi.org/10.1016/j.bmcl.2007.02.026
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author Ikejiri, Masahiro
Saijo, Masayuki
Morikawa, Shigeru
Fukushi, Shuetsu
Mizutani, Tetsuya
Kurane, Ichiro
Maruyama, Tokumi
author_facet Ikejiri, Masahiro
Saijo, Masayuki
Morikawa, Shigeru
Fukushi, Shuetsu
Mizutani, Tetsuya
Kurane, Ichiro
Maruyama, Tokumi
author_sort Ikejiri, Masahiro
collection PubMed
description Nucleoside analogues that have 6-chloropurine as the nucleobase were synthesized and evaluated for anti-SARS-CoV activity by plaque reduction and yield reduction assays in order to develop novel anti-SARS-CoV agents. Among these analogues, two compounds, namely, 1 and 11, exhibited promising anti-SARS-CoV activity that was comparable to those of mizoribine and ribavirin, which are known anti-SARS-CoV agents. Moreover, we observed several SAR trends such as the antiviral effects of the 6-chloropurine moiety, unprotected 5′-hydroxyl group and benzoylated 5′-hydroxyl group.
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spelling pubmed-71268752020-04-08 Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents Ikejiri, Masahiro Saijo, Masayuki Morikawa, Shigeru Fukushi, Shuetsu Mizutani, Tetsuya Kurane, Ichiro Maruyama, Tokumi Bioorg Med Chem Lett Article Nucleoside analogues that have 6-chloropurine as the nucleobase were synthesized and evaluated for anti-SARS-CoV activity by plaque reduction and yield reduction assays in order to develop novel anti-SARS-CoV agents. Among these analogues, two compounds, namely, 1 and 11, exhibited promising anti-SARS-CoV activity that was comparable to those of mizoribine and ribavirin, which are known anti-SARS-CoV agents. Moreover, we observed several SAR trends such as the antiviral effects of the 6-chloropurine moiety, unprotected 5′-hydroxyl group and benzoylated 5′-hydroxyl group. Elsevier Ltd. 2007-05-01 2007-02-13 /pmc/articles/PMC7126875/ /pubmed/17336519 http://dx.doi.org/10.1016/j.bmcl.2007.02.026 Text en Copyright © 2007 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ikejiri, Masahiro
Saijo, Masayuki
Morikawa, Shigeru
Fukushi, Shuetsu
Mizutani, Tetsuya
Kurane, Ichiro
Maruyama, Tokumi
Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents
title Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents
title_full Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents
title_fullStr Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents
title_full_unstemmed Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents
title_short Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents
title_sort synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-sars-cov agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126875/
https://www.ncbi.nlm.nih.gov/pubmed/17336519
http://dx.doi.org/10.1016/j.bmcl.2007.02.026
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