Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat

Peripheral T cell lymphopenia (lyp) in the BioBreeding (BB) rat is linked to a frameshift mutation in Ian5, a member of the Immune Associated Nucleotide (Ian) gene family on rat chromosome 4. This lymphopenia leads to type 1 (insulin-dependent) diabetes mellitus (T1DM) at rates up to 100% when combi...

Descripción completa

Detalles Bibliográficos
Autores principales: Moralejo, Daniel H., Park, Hyunhee A., Speros, Sara J., MacMurray, Armand J., Kwitek, Anne E., Jacob, Howard J., Lander, Eric S., Lernmark, Åke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd. 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126882/
https://www.ncbi.nlm.nih.gov/pubmed/14624755
http://dx.doi.org/10.1016/S0896-8411(03)00138-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126882/
https://www.ncbi.nlm.nih.gov/pubmed/14624755
http://dx.doi.org/10.1016/S0896-8411(03)00138-0

Ejemplares similares