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Temperature-sensitive mutants of mouse hepatitis virus strain A59: Isolation, characterization and neuropathogenic properties

Twenty 5-fluorouracil-induced temperature-sensitive (ts) mutants of mouse hepatitis virus strain A59 were isolated from 1284 virus clones. Mutants were preselected on the basis of their inability to induce syncytia in infected cells at the restrictive temperature (40°) vs the permissive temperature...

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Detalles Bibliográficos
Autores principales: Koolen, Marck J.M., Osterhaus, Albert D.M.E., Van Steenis, Gijsbert, Horzinek, Marian C., van der Zeijst, Bernard A.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 1983
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126919/
https://www.ncbi.nlm.nih.gov/pubmed/6301146
http://dx.doi.org/10.1016/0042-6822(83)90211-8