Synthesis and SAR studies on azetidine-containing dipeptides as HCMV inhibitors

SAR studies on an azetidine-containing dipeptide prototype inhibitor of HCMV are described. Three series of structurally modified analogues, involving substitutions at the N- and C-terminus, and at the C-terminal side-chain were synthesized and evaluated for antiviral activity. Aliphatic or no subst...

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Detalles Bibliográficos
Autores principales: Pérez-Faginas, Paula, Aranda, M. Teresa, García-López, M. Teresa, Snoeck, Robert, Andrei, Graciela, Balzarini, Jan, González-Muñiz, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127091/
https://www.ncbi.nlm.nih.gov/pubmed/21256035
http://dx.doi.org/10.1016/j.bmc.2010.12.052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127091/
https://www.ncbi.nlm.nih.gov/pubmed/21256035
http://dx.doi.org/10.1016/j.bmc.2010.12.052

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