Developmental toxicity in rats of a hemoglobin-based oxygen carrier results from impeded function of the inverted visceral yolk sac

HBOC-201 is a bovine-derived, cross-linked, and stabilized hemoglobin (250 kDa) in physiological saline. Daily intravenous infusions of HBOC (1.95, 3.90, or 5.85 g/kg/day) during gestational days (GDs) 6–18 in Sprague-Dawley rats caused fetal mortality, reduced birth weight, and malformations. Subse...

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Detalles Bibliográficos
Autores principales: Stump, D.G., Holson, J.F., Harris, C., Pearce, L.B., Watson, R.E., DeSesso, J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127137/
https://www.ncbi.nlm.nih.gov/pubmed/25617809
http://dx.doi.org/10.1016/j.reprotox.2015.01.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127137/
https://www.ncbi.nlm.nih.gov/pubmed/25617809
http://dx.doi.org/10.1016/j.reprotox.2015.01.005

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