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Evaluation of an octahydroisochromene scaffold used as a novel SARS 3CL protease inhibitor
An octahydroisochromene scaffold has been introduced into a known SARS 3CL protease inhibitor as a novel hydrophobic core to interact with the S2 pocket of the protease. An alkyl or aryl substituent was also introduced at the 1-position of the octahydroisochromene scaffold and expected to introduce...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127348/ https://www.ncbi.nlm.nih.gov/pubmed/31926775 http://dx.doi.org/10.1016/j.bmc.2019.115273 |