Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a carbamoyl linker

5-Arylcarbamoyl-2-methylisoxazolidin-3-yl-3-phosphonates have been synthesised from N-methyl-C-diethoxyphosphorylnitrone and N-arylacrylamides in good yields. cis- and trans-isoxazolidine phosphonates obtained herein were evaluated for activity against a broad range of DNA and RNA viruses. None of t...

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Detalles Bibliográficos
Autores principales: Kokosza, Kamil, Balzarini, Jan, Piotrowska, Dorota G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127400/
https://www.ncbi.nlm.nih.gov/pubmed/23380474
http://dx.doi.org/10.1016/j.bmc.2013.01.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127400/
https://www.ncbi.nlm.nih.gov/pubmed/23380474
http://dx.doi.org/10.1016/j.bmc.2013.01.007

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