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cGAS and CD-NTase enzymes: structure, mechanism, and evolution
Cyclic GMP–AMP synthase (cGAS) is a signaling enzyme in human cells that controls immune-sensing of cytosolic DNA. The recent discoveries of diverse structural homologs of cGAS in animals and bacteria reveal that cGAS-like signaling is surprisingly ancient and widespread in biology. Together with th...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Author. Published by Elsevier Ltd.
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127440/ https://www.ncbi.nlm.nih.gov/pubmed/31593902 http://dx.doi.org/10.1016/j.sbi.2019.08.003 |