Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors

A series of pyrazolone compounds as possible SARS-CoV 3CL protease inhibitors were designed, synthesized, and evaluated by in vitro protease assay using fluorogenic substrate peptide in which several showed potent inhibition against the 3CL protease. Interestingly, one of the inhibitors was also act...

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Detalles Bibliográficos
Autores principales: Ramajayam, R., Tan, Kian-Pin, Liu, Hun-Ge, Liang, Po-Huang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127448/
https://www.ncbi.nlm.nih.gov/pubmed/20947359
http://dx.doi.org/10.1016/j.bmc.2010.09.050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127448/
https://www.ncbi.nlm.nih.gov/pubmed/20947359
http://dx.doi.org/10.1016/j.bmc.2010.09.050

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