Cargando…

Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors

A series of pyrazolone compounds as possible SARS-CoV 3CL protease inhibitors were designed, synthesized, and evaluated by in vitro protease assay using fluorogenic substrate peptide in which several showed potent inhibition against the 3CL protease. Interestingly, one of the inhibitors was also act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramajayam, R., Tan, Kian-Pin, Liu, Hun-Ge, Liang, Po-Huang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127448/ https://www.ncbi.nlm.nih.gov/pubmed/20947359 http://dx.doi.org/10.1016/j.bmc.2010.09.050

Ejemplares similares

Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
por: Ramajayam, R., et al.
Publicado: (2010)

Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors
por: Kumar, Vathan, et al.
Publicado: (2016)

Catalytic and Multicomponent Reactions for Green Synthesis of Some Pyrazolone Compounds and Evaluation as Antimicrobial Agents
por: Ali, Hazim M., et al.
Publicado: (2022)

Design and synthesis of pyrazolone-based compounds as potent blockers of SARS-CoV-2 viral entry into the host cells
por: Obakachi, Vincent A., et al.
Publicado: (2021)

One-pot multistep mechanochemical synthesis of fluorinated pyrazolones
por: Howard, Joseph L, et al.
Publicado: (2017)

Individual and common inhibitors of coronavirus and picornavirus main proteases
por: Kuo, Chih-Jung, et al.
Publicado: (2009)

Pyrazolone-type compounds: synthesis and in silico assessment of antiviral potential against key viral proteins of SARS-CoV-2
por: Branković, Jovica, et al.
Publicado: (2022)

β-Enamino Esters in Heterocyclic Synthesis: Synthesis of Pyrazolone and Pyridinone Derivatives
por: Salaheldin, Abdellatif Mohamed, et al.
Publicado: (2010)

QSAR modeling and pharmacoinformatics of SARS coronavirus 3C-like protease inhibitors
por: Ishola, Ahmed Adebayo, et al.
Publicado: (2021)

Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors
por: Chen, Li-Rung, et al.
Publicado: (2005)

Synthesis of new pyrazolone and pyrazole-based adamantyl chalcones and antimicrobial activity
por: Al-Saheb, Rawan, et al.
Publicado: (2020)

Synthesis and Cytotoxic Evaluation of Some Substituted 5-Pyrazolones and Their Urea Derivatives
por: Gediz Erturk, Aliye, et al.
Publicado: (2020)

Development of Pyrazolone and Isoxazol-5-one Cambinol Analogues as Sirtuin Inhibitors
por: Mahajan, Sumit S., et al.
Publicado: (2014)

The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds
por: Báez-Santos, Yahira M., et al.
Publicado: (2015)

EVALUATION OF ANTIOXIDANT POTENTIAL OF PYRAZOLONE DERIVATIVES
por: Mariappan, G., et al.
Publicado: (2010)

An easy direct arylation of 5-pyrazolones
por: Gong, Hao, et al.
Publicado: (2013)

Synthesis of novel pyrazolone candidates with studying some biological activities and in-silico studies
por: Abdellattif, Magda H., et al.
Publicado: (2023)

Evaluation of the antimicrobial activity of novel composite plastics containing two silver (I) additives, acyl pyrazolonate and acyl pyrazolone
por: Scuri, Stefania, et al.
Publicado: (2019)

Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease
por: Kim, Yunjeong, et al.
Publicado: (2013)

Merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones
por: Zheng, Ya-Yun, et al.
Publicado: (2019)

Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of SARS-Coronavirus
por: Hartini, Yustina, et al.
Publicado: (2021)

Pyrazolone ligation-mediated versatile sequential bioconjugations
por: Mailig, Melrose, et al.
Publicado: (2020)

Two Inhibitors Against the 3C-Like Proteases of Swine Coronavirus and Feline Coronavirus
por: Zhou, Mengxin, et al.
Publicado: (2021)

Synergistic Inhibitor Binding to the Papain‐Like Protease of Human SARS Coronavirus: Mechanistic and Inhibitor Design Implications
por: Lee, Hyun, et al.
Publicado: (2013)

Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions
por: Ma, Ruoqun, et al.
Publicado: (2010)

Synthesis, Photoluminescence and Electrical Study of Pyrazolone-Based Azomethine Ligand Zn(II) Complexes
por: Gusev, Alexey, et al.
Publicado: (2020)

Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds
por: Lin, Cheng-Wen, et al.
Publicado: (2005)

Potential of coronavirus 3C-like protease inhibitors for the development of new anti-SARS-CoV-2 drugs: Insights from structures of protease and inhibitors
por: He, Jun, et al.
Publicado: (2020)

Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents
por: Kuo, Chih-Jung, et al.
Publicado: (2008)

Identification of non-covalent 3C-like protease inhibitors against severe acute respiratory syndrome coronavirus-2 via virtual screening of a Korean compound library
por: Lee, Joo-Youn, et al.
Publicado: (2021)

Evaluation of metal‐conjugated compounds as inhibitors of 3CL protease of SARS‐CoV
por: Hsu, John T.-A., et al.
Publicado: (2004)

Corrigendum to “Individual and common inhibitors of coronavirus and picornavirus main proteases” [FEBS Lett. 583 (2009) 549–555]
por: Kuo, Chih-Jung, et al.
Publicado: (2009)

Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds
por: Liu, Pei, et al.
Publicado: (2020)

Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole
por: Ariza, Adriana, et al.
Publicado: (2016)

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect
por: Zhao, Zefeng, et al.
Publicado: (2020)

Pyrazolone-type compounds (part II): in vitro and in silico evaluation of antioxidant potential; structure–activity relationship
por: Branković, Jovica, et al.
Publicado: (2023)

Proteases of SARS Coronaviruses
por: Mukherjee, Rukmini, et al.
Publicado: (2023)

Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
por: Fang, Feifei, et al.
Publicado: (2023)

New pyrazolone derivatives, synthesis, characterization, and neuroprotective effect against PTZ- induced neuroinflammation in mice
por: Kanwal, Madiha, et al.
Publicado: (2022)

Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases
por: Sanachai, Kamonpan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4amjbbtvo9jqjhm2l6c70lij98