Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain

The B cell adaptor protein (BCAP) is a multimodular regulator of inflammatory signaling in diverse immune system cells. BCAP couples TLR signaling to phosphoinositide metabolism and inhibits MyD88-directed signal transduction. BCAP is recruited to the TLR signalosome forming multitypic interactions...

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Detalles Bibliográficos
Autores principales: Lauenstein, Johannes U., Scherm, Michael J., Udgata, Atul, Moncrieffe, Martin C., Fisher, David I., Gay, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2020
Materias:
Molecular and Structural Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128310/
https://www.ncbi.nlm.nih.gov/pubmed/32198144
http://dx.doi.org/10.4049/jimmunol.1901210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128310/
https://www.ncbi.nlm.nih.gov/pubmed/32198144
http://dx.doi.org/10.4049/jimmunol.1901210

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