Cargando…

Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain

The B cell adaptor protein (BCAP) is a multimodular regulator of inflammatory signaling in diverse immune system cells. BCAP couples TLR signaling to phosphoinositide metabolism and inhibits MyD88-directed signal transduction. BCAP is recruited to the TLR signalosome forming multitypic interactions...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lauenstein, Johannes U., Scherm, Michael J., Udgata, Atul, Moncrieffe, Martin C., Fisher, David I., Gay, Nicholas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2020
Materias:	Molecular and Structural Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128310/ https://www.ncbi.nlm.nih.gov/pubmed/32198144 http://dx.doi.org/10.4049/jimmunol.1901210

Ejemplares similares

Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2
por: Lauenstein, Johannes U., et al.
Publicado: (2019)

MicroRNA-362-3p Inhibits Migration and Invasion via Targeting BCAP31 in Cervical Cancer
por: Yang, Shuya, et al.
Publicado: (2020)

Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome
por: Halabi, Samer, et al.
Publicado: (2017)

Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA
por: Garcia-Rodriguez, Gabriela, et al.
Publicado: (2021)

Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206
por: Liang, Yu, et al.
Publicado: (2012)

PRGF as adjunct to DBB in maxillary sinus floor augmentation: histological results of a pilot split-mouth study
por: Batas, Leonidas, et al.
Publicado: (2019)

The use of BCAP in Finland: toward correct classification rate
por: Eija, Paavilainen, et al.
Publicado: (2022)

Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain
por: Cheng, Xiankun, et al.
Publicado: (2019)

Crystal structure of the N-terminal domain of MinC dimerized via domain swapping
por: An, Jun Yop, et al.
Publicado: (2013)

Essential Immunoregulatory Role for BCAP in B Cell Development and Function
por: Yamazaki, Tetsuo, et al.
Publicado: (2002)

Rbg1–Tma46 dimer structure reveals new functional domains and their role in polysome recruitment
por: Francis, Sandrea M., et al.
Publicado: (2012)

DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions
por: Chen, Yongheng, et al.
Publicado: (2015)

PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1
por: Purbey, Prabhat Kumar, et al.
Publicado: (2008)

Crystal Structure of a Functional Dimer of the PhoQ Sensor Domain
por: Cheung, Jonah, et al.
Publicado: (2008)

Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk
por: Lee, Ka-Ming, et al.
Publicado: (2010)

Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site
por: Teixeira-Duarte, Celso M, et al.
Publicado: (2019)

NF45 dimerizes with NF90, Zfr and SPNR via a conserved domain that has a nucleotidyltransferase fold
por: Wolkowicz, Urszula M., et al.
Publicado: (2012)

Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states
por: Chadda, Rahul, et al.
Publicado: (2021)

Solution structure of the dimerization domain of the eukaryotic stalk P1/P2 complex reveals the structural organization of eukaryotic stalk complex
por: Lee, Ka-Ming, et al.
Publicado: (2012)

C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer
por: Zhong, Nan, et al.
Publicado: (2009)

CryoEM structures of open dimers of gyrase A in complex with DNA illuminate mechanism of strand passage
por: Soczek, Katarzyna M, et al.
Publicado: (2018)

Structure of an inactive RNA polymerase II dimer
por: Aibara, Shintaro, et al.
Publicado: (2021)

Visualization of ATP Synthase Dimers in Mitochondria by Electron Cryo-tomography
por: Davies, Karen M., et al.
Publicado: (2014)

Acidic C-terminal domains autoregulate the RNA chaperone Hfq
por: Santiago-Frangos, Andrew, et al.
Publicado: (2017)

Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase
por: Ritacco, Christopher J., et al.
Publicado: (2013)

Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR
por: Hao, Nan, et al.
Publicado: (2011)

Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability
por: Pavelich, Ian J, et al.
Publicado: (2019)

The archaeo-eukaryotic primase of plasmid pRN1 requires a helix bundle domain for faithful primer synthesis
por: Beck, Kirsten, et al.
Publicado: (2010)

Activation of Toll-like receptor 4 by Ebola virus-shed glycoprotein is direct and requires the internal fusion loop but not glycosylation
por: Scherm, Michael J., et al.
Publicado: (2022)

Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1
por: Knott, Gavin J, et al.
Publicado: (2021)

Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms
por: Huffer, Katherine E, et al.
Publicado: (2020)

Functional implications of MIR domains in protein O-mannosylation
por: Chiapparino, Antonella, et al.
Publicado: (2020)

Ca(2+) Regulates Dimerization of the BAR Domain Protein PICK1 and Consequent Membrane Curvature
por: Stan, Georgiana F., et al.
Publicado: (2022)

Solution Structure of Tubuliform Spidroin N-Terminal Domain and Implications for pH Dependent Dimerization
por: Šede, Megija, et al.
Publicado: (2022)

Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A(2)α
por: Hirano, Yoshinori, et al.
Publicado: (2019)

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers
por: Baburajendran, Nithya, et al.
Publicado: (2011)

Structural insights into the dimerization of the response regulator ComE from Streptococcus pneumoniae
por: Boudes, Marion, et al.
Publicado: (2014)

Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA
por: Tamulaitiene, Giedre, et al.
Publicado: (2017)

Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA
por: Patel, Abdul Kareem Mohideen, et al.
Publicado: (2023)

The structural basis for partitioning of the XRCC1/DNA ligase III-α BRCT-mediated dimer complexes
por: Cuneo, Matthew J., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ua12hcal436tfogq7mo5gdddo7