Therapeutic and diagnostic implications of Hsp90 activation

The molecular chaperone heat-shock protein 90 (Hsp90) is involved in the stabilization and conformational maturation of many signaling proteins that are deregulated in cancers. Hsp90 inhibition results in the proteasomal degradation of these client proteins and leads to potent antitumor activity. Th...

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Detalles Bibliográficos
Autores principales: Kamal, Adeela, Boehm, Marcus F, Burrows, Francis J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128344/
https://www.ncbi.nlm.nih.gov/pubmed/15177193
http://dx.doi.org/10.1016/j.molmed.2004.04.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128344/
https://www.ncbi.nlm.nih.gov/pubmed/15177193
http://dx.doi.org/10.1016/j.molmed.2004.04.006

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