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Template-based coiled-coil antigens elicit neutralizing antibodies to the SARS-coronavirus
The Spike (S) glycoprotein of coronaviruses (CoV) mediates viral entry into host cells. It contains two hydrophobic heptad repeat (HR) regions, denoted HRN and HRC, which oligomerize the S glycoprotein into a trimer in the native state and when activated collapse into a six-helix bundle structure dr...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129695/ https://www.ncbi.nlm.nih.gov/pubmed/16697221 http://dx.doi.org/10.1016/j.jsb.2006.03.019 |