The Iterative Gramicidin S Thioesterase Catalyzes Peptide Ligation and Cyclization

Here, we present a comprehensive in vitro characterization of the excised iterative, bimodular PCP-TE of the gramicidin S synthetase GrsB, which is able to act both as a ligation and a cyclization catalyst. Using the native pentapeptidyl-thioester substrates, GrsB PCP-TE catalyzes the dimerization a...

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Detalles Bibliográficos
Autores principales: Hoyer, Katharina M., Mahlert, Christoph, Marahiel, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129787/
https://www.ncbi.nlm.nih.gov/pubmed/17254948
http://dx.doi.org/10.1016/j.chembiol.2006.10.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129787/
https://www.ncbi.nlm.nih.gov/pubmed/17254948
http://dx.doi.org/10.1016/j.chembiol.2006.10.011

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