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The Iterative Gramicidin S Thioesterase Catalyzes Peptide Ligation and Cyclization
Here, we present a comprehensive in vitro characterization of the excised iterative, bimodular PCP-TE of the gramicidin S synthetase GrsB, which is able to act both as a ligation and a cyclization catalyst. Using the native pentapeptidyl-thioester substrates, GrsB PCP-TE catalyzes the dimerization a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129787/ https://www.ncbi.nlm.nih.gov/pubmed/17254948 http://dx.doi.org/10.1016/j.chembiol.2006.10.011 |