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Hypothesis links emergence of chloroquine-resistant malaria and other intracellular pathogens and suggests a new strategy for treatment of diseases caused by intracellular parasites
Chloroquine and related anti-malarial drugs appear to promote apoptosis in T-cells by suppressing NF-kappa-B, which enhances the expression of anti-apoptotic proteins (e.g., Bcl-2). Thus, chloroquine has found applications in autoimmune diseases where it apparently facilitates apoptosis of abnormall...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Ltd.
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130919/ https://www.ncbi.nlm.nih.gov/pubmed/14975502 http://dx.doi.org/10.1016/j.mehy.2003.12.004 |